Question · Answered

What Is Acetylcholine?

As the primary neurotransmitter involved in sweat production, acetylcholine plays a key role in hyperhidrosis and many of its treatment options.
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Answered by

Dr. Eraj Basseri, M.D.

Acetylcholine is a neurotransmitter (a messenger in laymen terms) that is a very active ingredient in the autonomic nervous system (sympathetic and parasympathetic). As a neurotransmitter (messenger) it is the chemical structure that triggers sweat production. There are many other actions being caused by this neurotransmitter but this is not the place to talk about those. Most of the conservative measures to treat hyperhidrosis start with oral intake of anti-acetyl choline medications and hence the name anticholinergic agents i.e. Robinul, Propantheline, Ditropan. The success rate associated with these medications with moderate to severe cases of hyperhidrosis is extremely low. Having said that it is the first line of defense when someone tries to treat hyperhidrosis. Side effects such as blurry vision or dry mouth can happen but in the lower dosage range it’s very unusual. It should also be known that with time efficiency can go down because of the bodies built up resistance (anti bodies). As with any other oral medication if there is a need for higher dosages then one should be aware of the side effects. Consult your physician / pharmacist with regard to that.

Acetylcholine

The primary neurotransmitter responsible for activating sweat glands.

First-Line

Many hyperhidrosis treatments begin with anticholinergic medications.

Variable

Results and long-term effectiveness can differ from patient to patient.

For people with hyperhidrosis, the problem isn't the sweat glands—it's the message telling them to keep producing sweat.

Dr. Eraj Basseri

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